MOTS-c

MOTS-c is a 16-amino-acid peptide (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg) derived from the mitochondrial genome, encoded within the 12S rRNA region. Classified as a mitochondrial-derived peptide (MDP), MOTS-c has become a significant focus of research in the fields of cellular energy regulation, stress resistance, and aging biology.

In laboratory settings, MOTS-c has been observed to modulate AMPK signaling, promote metabolic homeostasis, and interact with pathways that influence mitochondrial performance. It is widely used in non-clinical studies investigating peptide-based mitochondrial communication, systemic energy balance, and exercise adaptation models.

• Peptide Type: Mitochondrial-Derived Peptide (MDP)
• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
• Purity: ≥99% (HPLC-verified)
• Molecular Focus: Mitochondrial signaling, AMPK activation, energy regulation
• Applications: Aging research, metabolic stress response, mitochondrial homeostasis
• Format: Lyophilized peptide, 40mg vial
• Use Case: Laboratory research only

• Mitochondrial communication with the nucleus
• Regulation of cellular energy and nutrient sensing
• Systemic metabolic homeostasis

While originally believed to act only within mitochondria, MOTS-c has now been detected in the nucleus and in circulation, confirming its role as a bona fide hormone-like signaling molecule.

Key areas of research interest include:

• Metabolism and weight regulation
• Exercise capacity and fatigue resistance
• Insulin sensitivity and glucose handling
• Bone remodeling and osteoporosis models
• Longevity and age-related functional decline
• Cardiometabolic and vascular health

MOTS-c has become a focus of intensive metabolic and gerontology research over the last several years due to its potential to modulate energy pathways that were historically accessible mainly through dietary restriction or exercise.