Thymosin Alpha-1
Original price was: $59.00.$47.20Current price is: $47.20.
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Transparency is our priority. Download the full HPLC and Mass Spectrometry reports for the current batch #88291. Tested on Oct 24, 2023.
DOWNLOAD FULL REPORT (PDF)Thymosin Alpha-1 (Tα1) is a synthetic research peptide composed of 28 amino acids, originally derived from the biologically active fraction of thymic hormones. It has been widely studied in preclinical models for its immunomodulatory properties, particularly its effects on T-cell maturation and cytokine regulation.
Experimental research shows Tα1 interacts with pattern recognition receptors and plays a key role in immune signaling, including toll-like receptor (TLR) pathways and MyD88/NF-κB cascades. This peptide is frequently used in immunology-focused studies aimed at understanding host-defense mechanisms and regulatory signaling networks.
- Peptide Type: Synthetic polypeptide
- Sequence Length: 28 amino acids
- Common Alias: Thymalfasin
- Primary Use: Immune system modulation in preclinical studies
- Mechanism Target: MyD88/NF-κB pathway, toll-like receptors, T-cell pathways
- For Research Use Only: Not for clinical or therapeutic application
1. T-Cell Function and Differentiation Studies
Tα1 is commonly used to explore mechanisms of T-cell development, activation, and signaling. It has been shown to influence CD4+/CD8+ ratios and enhance effector responses in immunocompromised models.
2. Toll-Like Receptor (TLR) and Pattern Recognition Pathways
In vitro assays highlight Tα1's role in modulating TLR-mediated innate immune responses. It activates MyD88-dependent signaling, leading to upregulation of NF-κB and downstream cytokine expression.
3. Cytokine Modulation and Immune Balance
Thymosin Alpha-1 is utilized in research evaluating cytokine regulation, particularly IL-2, IFN-γ, and TNF-α. It has been shown to support immune balance in stress and inflammation models.
4. Antigen Presentation and APC Maturation
Experimental studies indicate enhanced dendritic cell maturation and increased expression of MHC class I and II molecules under Tα1 influence, supporting its use in antigen presentation and vaccine research paradigms.
5. Host Defense and Stress Response
Tα1 is employed in infection and immune-compromised models to examine its effect on restoring immune competence, supporting research into peptide-mediated resistance mechanisms and systemic resilience.
Q: What is Thymosin Alpha-1 derived from?
A: It is a synthetic version of a naturally occurring thymic peptide found in thymic extracts, originally identified as part of thymosin fraction 5.
Q: What signaling pathways does Thymosin Alpha-1 affect?
A: Primarily toll-like receptors and the MyD88/NF-κB pathway, along with T-cell activation pathways and cytokine gene regulation.
Q: What are typical research models using Thymosin Alpha-1?
A: It is commonly used in immunodeficiency, infection, inflammation, and cancer-related immune regulation models.
Q: Is Thymosin Alpha-1 used therapeutically?
A: While Thymosin Alpha-1 has been studied in clinical trials, this version is strictly intended for laboratory research use only.
Q: Does Thymosin Alpha-1 influence both innate and adaptive immunity?
A: Yes. It has been shown to impact T-cell responses, antigen-presenting cell maturation, and cytokine release associated with innate immunity.
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