LL-37 5mg
Original price was: $105.00.$84.00Current price is: $84.00.
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Transparency is our priority. Download the full HPLC and Mass Spectrometry reports for the current batch #88291. Tested on Oct 24, 2023.
DOWNLOAD FULL REPORT (PDF)LL-37 is a human-derived antimicrobial peptide from the cathelicidin family that is widely studied for its role at the interface of host defense, inflammation, and tissue remodeling. In experimental models, LL-37 demonstrates broad-spectrum activity against bacteria, viruses, and fungi, while also interacting with immune and structural cells to influence inflammatory signaling, barrier integrity, and blood vessel formation.
As a research-only peptide, LL-37 is used to investigate innate immunity, inflammatory disease mechanisms, wound-repair biology, and tumor microenvironment dynamics. It is not approved for therapeutic, cosmetic, or diagnostic use in humans or animals.
LL-37 is the only known human cathelicidin-derived peptide and is generated by proteolytic processing of the CAP18 precursor protein. It is expressed in various epithelial surfaces and immune cells, especially at barrier sites such as skin, airways, and the gastrointestinal tract.
Key characteristics of LL-37 in research contexts include:
- Innate immune effector: Interacts with microbial membranes and host pattern-recognition systems.
- Immunomodulator: Can either enhance or restrain inflammatory responses depending on cell type, activation state, and local cytokine milieu.
- Tissue homeostasis mediator: Has been studied in relation to epithelial repair, angiogenesis, and extracellular matrix remodeling.
Because LL-37 shows context-dependent behavior, it serves as a versatile probe for exploring how a single peptide can coordinate antimicrobial defense with controlled inflammation and tissue repair.
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.
- On arrival: Store vials in a cool, dry place away from heat and direct sunlight.
- Long-term (powder): For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
- After reconstitution: Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Note: Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Q1: What is LL-37 primarily used for in research?
A1: LL-37 is used to study innate immunity, antimicrobial defense, inflammatory signaling, tissue repair, and angiogenesis. It serves as a model peptide for understanding how one molecule can bridge host defense, immune modulation, and structural tissue responses.
Q2: Is LL-37 considered an antibiotic or a drug for treating infections?
A2: No. While LL-37 displays antimicrobial activity in experimental systems, LL-37 supplied for research is not approved or marketed as an antibiotic or therapeutic product. It is a research-only peptide used to explore host–pathogen interactions and innate immune mechanisms.
Q3: How does LL-37 affect inflammation in experimental models?
A3: LL-37 may either enhance or restrain inflammatory responses depending on cell type, activation state, and local cytokines. It has shown effects on cytokine production, cell recruitment, and pattern-recognition receptor signaling, making it a key peptide for investigating immune homeostasis rather than a simple pro- or anti-inflammatory factor.
Q4: Is LL-37 being investigated in connection with autoimmune or joint diseases?
A4: Yes. LL-37 has been detected in inflamed joints and has been studied in models of rheumatoid arthritis and other immune-mediated conditions. Current research focuses on its potential role as a modulator of inflammation and tissue damage, not as a confirmed therapeutic.
Q5: Can LL-37 be used for human therapy, cosmetic purposes, or self-administration?
A5: No. LL-37 distributed by research suppliers is intended strictly for laboratory use by qualified professionals. It is not approved for human or veterinary administration, cosmetic use, or any self-use application.
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