VIP

Vasodilator Research

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SCIENTIFIC SPECIFICATIONS

Molecular Formula

C147H238N44O42S

CAS

137525-51-0

Molar Mass

773.895 g/mol

Amino Acid Sequence

His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn

Synonyms

VIP, Vasoactive Intestinal Polypeptide, PHM27

Solubility

Soluble in Water

Organoleptic Profile

White powder

Composition

Lyophilized powder – requires reconstitution

Research Use Only

● VERIFIED ANALYSIS

Third-Party Lab Results

Transparency is our priority. Download the full HPLC and Mass Spectrometry reports for the current batch #88291. Tested on Oct 24, 2023.

DOWNLOAD FULL REPORT (PDF)

PDF

HPLC_BPC157_Batch88291.pdf

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PDF

MS_BPC157_Batch88291.pdf

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Research Overview

VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide belonging to the secretin/glucagon peptide family. It binds to G protein–coupled receptors VPAC1 and VPAC2 to activate cAMP-dependent signaling pathways that mediate smooth muscle relaxation, vasodilation, immune modulation, and neuroendocrine communication.

VIP is widely used in research models to explore peptide-regulated vascular tone, neuroimmune interactions, epithelial homeostasis, and anti-inflammatory signaling. Its distribution across central and peripheral tissues makes it a versatile tool in both neuroscience and immunophysiology studies.

Peptide Name: Vasoactive Intestinal Peptide (VIP)
Sequence: HSDAVFTDNYSRVRSRFLEYSCRKRKQQ-NH₂
Length: 28 amino acids
Molecular Weight: ~3,327 Da
Receptor Targets: VPAC1, VPAC2 (Class B GPCRs)
Purity: ≥98% (HPLC verified)
Format: Lyophilized powder, 10mg vial

Use: For laboratory research only, not for clinical or diagnostic use

Storage & Handling

All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.

On arrival: Store vials in a cool, dry place away from heat and direct sunlight.
Long-term (powder): For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
After reconstitution: Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.

Note: Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.

FAQ

Q: What receptors does VIP target?
A: VIP primarily binds to VPAC1 and VPAC2 receptors, activating cAMP-mediated intracellular signaling cascades.

Q: Is VIP used in cardiovascular research?
A: Yes, due to its potent vasodilatory effects, VIP is often studied for its impact on vascular tone and smooth muscle relaxation.

Q: Does VIP play a role in immune modulation?
A: Yes, VIP has been shown to regulate immune responses by modulating cytokine production and inflammatory signaling.

Q: Can VIP be used in brain research?
A: Absolutely. VIP is involved in neurotrophic signaling, synaptic maintenance, and neuron-glia interactions, making it valuable in CNS-focused research.

Q: Is this peptide intended for clinical use?
A: No. VIP 10mg is strictly for laboratory research and preclinical use. It is not approved for human consumption or therapeutic applications.

Research Use Only: This product is intended for laboratory research use only and is not for human consumption, diagnostic, or therapeutic use.